Acetophenone thiosemicarbazone (APTSC) was synthesized. Solubility of APTSC was determined in ethanol and methanol at different temperatures. Thiosemicarbazone p-Substituted Acetophenone Derivatives Promote the Loss of Mitochondrial, GSH Depletion, and Death in K Cells. Sample records for acetophenone thiosemicarbazones synthesis The complex compounds of rhenium with methyl ident thiosemicarbazone were synthesized.
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Synthesis of complex compounds in the system [ReOG5] thiosemicarbazone acetone-Hg-acetone. Present article is devoted to synthesis of complex compounds in the system [ReOG 5 ] 2- – thiosemicarbazone acetone-Hg-acetone. The literature data on complex compounds of various metals with thiosemicarbazone was summarized.
The synthesis of complex compounds in the system [ReOG 5 ] 2- – thiosemicarbazone acetone-Hg-acetone was conducted. The complex compounds of rhenium with methyl ident thiosemicarbazone were synthesized. A simple, efficient and eco-friendly method for the synthesis of thiosemicarbazones thiosemicarbaaone thiosemicarbazides and aldehyde under microwave irradiation has been reported, and no solvent and catalyst were used. And the technique of microwave irradiation coupled with solvent-free condition proved to be a quite valuable method in the organic synthesis.
Synthesis and cytotoxicity evaluation of thiosemicarbazones and their thiazole derivatives. Directory of Open Access Journals Sweden.
Full Text Available ABSTRACT The aims of this study were to synthesize xcetophenone series of thiosemicarbazones and their thiazole derivatives, to investigate their cytotoxic activity against three human cancers and normal Vero cells cell lines, and to evaluate the pro-apoptotic potential of the most active compounds.
The pro-apoptotic effect was measured by flow cytometry as the percentage of cells with hypodiploid DNA. Among the synthesized compounds, one in particular was found to exert antiproliferative and pro-apoptotic activity on tumor cells and can be considered promising as a lead molecule for the design of new analogues with improved activity. Synthesisphysicochemical and optical properties of bis- thiosemicarbazone functionalized graphene oxide. Kumar, Santosh; Wani, Mohmmad Y.
Fluorescent materials are important for low-cost opto-electronic and biomedical sensor devices. In this study we present the synthesis and characterization of graphene modified with bis- thiosemicarbazone BTS. Optical properties of BTSGO evaluated by photoluminescence PL spectroscopy showed red shift at different excitation wavelength compared to graphene oxide or bisthiosemicarbazide alone. These results strongly suggest that BTSGO material could find potential applications in graphene based optoelectronic devices.
The paper presents the synthesis of the ligand 1- 2-hydroxyphenyl ethanone N 4 -allyl thiosemicarbazone H2L and six coordination compounds of copper, nickel and cobalt with this ligand. The synthesized coordination compounds were studied using elemental analysis, gravimetric analysis of water content, molar conductivity, and magnetochemistry.
For H2L the antitumor activity towards human leukemia HL ce Substitution at the S atom].
The synthesis of S-substituted derivatives of 1,4-benzoquinone-guanylhydrazone- thiosemicarbazone is described. Thiossemicarbazone obtained 1,4-benzoquinone-guanylhydrazone-S-alkyl resp.
Therefore the S-substitution seems not to be useful for reaching a maximum activity. Synthesis of biological active thiosemicarbazone and characterization of the interaction with human serum albumin. The synthesis of a new biological active reagent, 2- 1,4-dihydroxy -9,anthraquinone aldehyde thiosemicarbazone Thiosemicabazonewas designed.
According to the results of fluorescence measurements, the quenching mechanism was suggested to be static. The thermodynamic parameters are calculated by van’t Hoff equation, which demonstrated that hydrophobic interactions are the predominant intermolecular forces stabilizing the complex.
The number of binding sites n was calculated. The experimental results were in agreement acetopenone the results obtained via a molecular docking study. Black-Right-Pointing-Pointer Hydrophobic interactions were the predominant intermolecular forces. All the complexes were found to have magnetic moments corresponding to three unpaired electrons. The acetophenons geometries of the complexes were assigned on the basis of electronic infrared and EPR spectral studies. Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L.
Upregulation of cathepsin L in a variety of tumors and its ability to promote cancer cell invasion and migration through degradation of the extracellular matrix suggest that cathepsin L is a promising biological target for the development of anti-metastatic agents.
Based on encouraging results from Low cytotoxicity, inhibition of cell invasion, and in vivo tolerability are desirable characteristics for anti-metastatic agents functioning through an inhibition of cathepsin L Full Text Available Synthesis of flavanoid compounds of chalcone and flavanone groups have been conducted.
Flavanoid Is one of the group natural products which is mostly found in plants and have been proved to have physiological activity as drug. In this research, chalcone proup compounds that being synthesized are: The synthesis of chalcone group are carried out based on Claisen-Schmidt reaction qcetophenone using thioswmicarbazone material of aromatic aldehydes and aromatic ketones.
The synthesis in carried out by stirring at the room temperature using afetophenone solution as catalyst and ethanol as solvent. The synthesis is made by refluxing 2′-hydroxy-3,4-dimethoxychalcone in alkali condition for 12 hours.
Acetophenone thiosemicarbazone supplier | CasNO
The result of each synthesis chalcone group are follows: Synthesis and antimicrobial activities of new 4-thiazolidones derived from formipyridine thiosemicarbazones. Twelve novel 4-thiazolidinone derivatives 2a-l have been synthesized by reacting formylpyridine thiosemicarbazones 1a-l and anhydride maleic in toluene.
The new compounds were submitted to in vitro evaluation against pathogenic Gram-positive, Gram-negative bacteria and yeasts. The findings obtained showed that the compounds 2a, 2d, 2e and 2g were effective against some of the bacterial strains used, whereas the compounds 2d, 2e and 2i exhibited a moderate antifungal activity against the yeast strains evaluated.
An initial structure activity relationship SAR was established. Inhibition of bovine viral diarrhea virus RNA acetophenpne by thiosemicarbazone derived from 5,6-dimethoxyindanone. In the present work, we described the activity of the thiosemicarbazone derived from 5,6-dimethoxyindanone TSCwhich we previously characterized as a new compound that inhibits bovine viral diarrhea virus BVDV infection.
The remaining mutant showed an AE mutation within the same protein. Some of these mutants replicated slower than the wild-type wt virus in the absence of TSC, whereas others showed a partial reversion to the wt phenotype over several passages in the absence of the compound. The docking of TSC in the crystal structure of the BVDV RdRp revealed a close contact between the indane ring of the compound and several residues within the fingers domain of the enzyme, some hydrophobic thiosemicarbazohe, and hydrogen bonds with the thiosemicarbazone group.
Synthesisbiological evaluation and molecular docking of N-phenyl thiosemicarbazones as urease inhibitors. Urease is an important enzyme which breaks urea into ammonia and carbon dioxide during metabolic processes.
Acetpohenone, an elevated activity of urease causes various complications of clinical importance. The inhibition of urease activity with small molecules as inhibitors is an effective strategy for therapeutic intervention.
Herein, we have synthesized a series of 19 benzofurane linked N-phenyl semithiocarbazones 3a-3s. All the compounds were screened for enzyme inhibitor activity against Jack bean urease. The synthesized N-phenyl thiosemicarbazones had varying activity levels with IC50 values between 0.
The activities of these compounds may be due to their close resemblance of thiourea. Ruthenium II complexes of thiosemicarbazone: Synthesisbiosensor applications and evaluation as antimicrobial agents.
The peripheral TSC in the complexes acts as an electrochemical coupling unit providing the ability to carry out electrochemical deposition ED and to form an electro-deposited film on a graphite electrode surface. The biosensing applicability of complexes 1 and 2 was investigated by using glucose oxidase GOx as a model enzyme. The designed biosensor showed a very good linearity for 0. The thiowemicarbazone vitro antimicrobial activities of complexes 1 and 2 were also investigated against nine bacterial strains and one fungus by the disc diffusion test method.
No activity was observed against the Gram-negative strains and fungus, whereas complex 1 showed moderate antibacterial activities against Gram-positive bacterial strains. Synthesis and prospective study of the use of thiophene thiosemicarbazones as signalling scaffolding for the recognition of anions.
A family of phenyl- thiosemicarbazone dyes have been prepared and their interactions with anions monitorized via UV-Vis, fluorescence and 1H NMR titrations. Additionally quantum chemical calculations and electrochemical studies completed the studies carried out. The phenyl- thiosemicarbazone dyes show thosemicarbazone modulation of their hydrogen-bonding and electron-donating capabilities as a function of the chemical groups attached and display two different chromo-fluorogenic responses towards anions in ace Full Text Available In an effort to develop potent antimicrobial agents, new thiosemicarbazone derivatives were synthesized via the reaction of 4-[4- trifluoromethylphenyl]thiosemicarbazide with aromatic aldehydes.
The compounds were evaluated for their inhibitory effects on pathogenic bacteria and yeasts using the CLSI broth microdilution method. Microplate Alamar Blue Assay was also carried out to determine the antimycobacterial activities of the compounds against Mycobacterium tuberculosis H37Rv.
Among these derivatives, compounds 5 and 11 were more effective against Enterococcus faecalis ATCC than chloramphenicol, whereas compounds 1, 2, and 12 and chloramphenicol showed the same level of antibacterial activity against E. Moreover, compound 2 and chloramphenicol exhibited the same level of antibacterial activity against Staphylococcus aureus.
On the other hand, the most potent anticandidal derivatives were found as compounds 2 and 5. These derivatives and ketoconazole exhibited the same level of antifungal activity against Candida glabrata.
According to the Microplate Alamar Blue Assay, the tested compounds showed weak to moderate antitubercular activity. Synthesis of isatin thiosemicarbazones derivatives: New derivatives of thiosemicarbazone Schiff base with isatin moiety were synthesized L1-L6. The structures of these compounds were characterized based on the spectroscopic techniques. Compound L6 was further characterized by XRD single crystal. This result was also confirmed by the viscosity data. The electrophoresis studies reveal the higher cleavage activity of L1-L3 than L4-L6.
The in vitro anti-proliferative activity of these compounds against human colon cancer cell line Thiosemicarbazonf revealed that the synthesized compounds L3, L6 and L2 exhibited good anticancer potency.
The results were compared with the marketed drugs. The crystal structure was determined by single x-ray diffraction. The compounds were screened for antibacterial properties and exhibited potential activity.
Complex 6 shows a square planar geometry with two deprotonated ligands coordinated to PdII through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. Among all the studied palladium II complexes, the [Pd TSC3 2] 8 complex exhibited high antitumor activity on the DU prostate carcinoma and K chronic myelogenous leukemia cells, with low values of the thiosemicarbaxone concentration 0.
The coordination characteristic of the investigated thiosemicarbazones towards hazard pollutants, Cd II and Hg IIbecomes the first goal. Their complexes have been studied by microanalysis, thermal, electrochemical and spectral electronic, IR and MS studies.
The substitutent salicylaldehyde, acetophenonebenzophenone, o-hydroxy- p-methoxybenzophenone or diacetylmonoxime plays an important role in the complex formation. The kinetic and thermodynamic parameters for the different thermal decomposition steps in the complexes thioxemicarbazone been evaluated. The activation energy values of the caetophenone step ordered the complexes as: